BT LAB

Artikelnummer: BT-E3234Hu-96T

Human Rho Guanine Nucleotide Exchange Factor 1, ARHGEF1 ELISA Kit, 96T

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed: 9641915, PubMed: 9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed: 9641915, PubMed: 9641916, PubMed: 8810315, PubMed: 30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed: 9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed: 9641916). Mediates angiotensin-2-induced RhoA activation (PubMed: 20098430).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:2.79ng/L

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Application:ELISA

Detection Target:ARHGEF1

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Detection Range: 5-1000ng/L

Research Areas:Others

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Assay Time:1h 30m

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