BT LAB

Artikelnummer: BT-E6726Hu-96T

Human Transcription Factor A, Mitochondrial, TFAM ELISA Kit, 96T

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed: 29445193, PubMed: 32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed: 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed: 20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed: 22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed: 22037172). Is able to unwind DNA (PubMed: 22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed: 1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed: 22841477, PubMed: 19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed: 22037171).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.17ng/L

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Application:ELISA

Detection Target:TFAM

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Detection Range: 10-2000ng/L

Research Areas:Tags & Cell Markers

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Test Principle:Sandwich

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Assay Time:1h 30m

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