BT LAB

Artikelnummer: BT-E2134Mo-96T

Mouse Histone Deacetylase 6, HDAC6 ELISA Kit, 96T

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed: 9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed: 9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed: 9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed: 19893491). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed: 22819792).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:7.34ng/L

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Application:ELISA

Detection Target:HDAC6

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Detection Range: 15-3000ng/L

Research Areas:Others

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Reactivity:Mouse

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Test Principle:Sandwich

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Assay Time:1h 30m

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