{"product_id":"af-4-polyclonal-antibody-100ul","title":"AF-4 Polyclonal Antibody, 100ul","description":"\u003cp\u003eAFF1 encodes a member of the AF4\/ lymphoid nuclear protein related to AF4\/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4\/ lymphoid nuclear protein related to AF4\/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, AFF1has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516117037429,"sku":"BT-AP00284-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/af-4-polyclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}