Antibody Humanization

Synbio Technologies has developed an integrated antibody humanization and affinity maturation platform based on the advanced phage/yeast display technologies and progressive computer modeling and simulation techniques. Our antibody humanization services include in silico CDR-grafting, computer-aided design and optimization, high-throughput screening of phage-display antibodies, and Biacore surface resonance analysis. With this approach, we are able to provide humanized antibodies with diminished immunogenicity, which have comparable or better specificity, bioactivity, thermos-stability, and productivity than parental antibodies.