{"product_id":"bcar1-rabbit-polyclonal-antibody-50ul","title":"BCAR1 Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eA serine-rich region promotes activation of the serum response element (SRE).|Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK| NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.|The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.|Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.|PTM:Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.|Belongs to the CAS family.|Contains 1 SH3 domain.|subcellular location:Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.|subunit:Forms complexes in vivo with focal adhesion kinase 1| adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with BCAR3| NPHP1| PTK2B and SH2D3C (By similarity). Interacts with activated CSPG4. Interacts with INPPL1\/SHIP2.|tissue specificity:Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver| thymus| and peripheral blood leukocytes. The protein has been detected in a B-cell line.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514748383605,"sku":"BT-AP06283-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/de\/products\/bcar1-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}