{"product_id":"bovine-t-cell-surface-glycoprotein-cd8-alpha-chain-cd8a-elisa-kit-96t","title":"Bovine T-cell Surface Glycoprotein Cd8 Alpha Chain, CD8A ELISA Kit, 96T","description":"\u003cp\u003eIntegral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I Peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592449700213,"sku":"BT-E0326Bo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/bovine-t-cell-surface-glycoprotein-cd8-alpha-chain-cd8a-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}