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Artikelnummer: E-AB-30669_60μL-ES
BRCA1 Polyclonal Antibody, 60 μL
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Speicher: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Haltbarkeit: 12 months
Herkunftsort: China
Technical Specifications
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Concentration:1 mg/mL
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Calculated Molecular Weight:208kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:208kDa
Dilution:WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000
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Konzentration: 1 mg/mL
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Anwendung: WB;IHC-p;IF
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