{"product_id":"casein-kinase-igamma2-polyclonal-antibody-100ul","title":"Casein Kinase IGamma2 Polyclonal Antibody, 100ul","description":"\u003cp\u003eSerine\/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP\/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP\/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516144464245,"sku":"BT-AP01185-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/casein-kinase-igamma2-polyclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}