{"product_id":"cic-polyclonal-antibody-20ul","title":"CIC Polyclonal Antibody, 20ul","description":"\u003cp\u003eThe protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56518251413877,"sku":"BT-AP07707-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_2.jpg?v=1766710711","url":"https:\/\/www.labcart.com\/de\/products\/cic-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}