{"product_id":"clcn3-rabbit-polyclonal-antibody-20ul","title":"CLCN3 Rabbit Polyclonal Antibody, 20ul","description":"\u003cp\u003eThis gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes| and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles| and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)\/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56508818030965,"sku":"BT-AP08024-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_3.jpg?v=1766971577","url":"https:\/\/www.labcart.com\/de\/products\/clcn3-rabbit-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}