{"product_id":"dclk1-rabbit-polyclonal-antibody-50ul","title":"DCLK1 Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eThis gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains| which bind microtubules and regulate microtubule polymerization| a C-terminal serine\/threonine protein kinase domain| which shows substantial homology to Ca2+\/calmodulin-dependent protein kinase| and a serine\/proline-rich domain in between the doublecortin and the protein kinase domains| which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes| including neuronal migration| retrograde transport| neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported| but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms| which are differentially expressed and have different kinase activities.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514843115893,"sku":"BT-AP02175-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/dclk1-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}