{"product_id":"e2a-polyclonal-antibody-50ul","title":"E2A Polyclonal Antibody, 50ul","description":"\u003cp\u003eTCF3 (transcription factor 3) encodes a member of the E protein  (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding  (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of TCF3 or diminished activity of the encoded protein may play a role in lymphoid malignancies. TCF3 is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia  (t (1; 19), with PBX1), childhood leukemia  (t (19; 19), with TFPT) and acute leukemia  (t (12; 19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for TCF3, and a pseudogene of TCF3 is located on the short arm of chromosome 9.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56513661927797,"sku":"BT-AP02783-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/e2a-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}