- Specification
- Downloads
- Reviews
€97,20
ADD TO CART
BT LAB
Artikelnummer: BT-AP10068-20ul
FOS Rabbit Polyclonal Antibody, 20ul
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer| c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction| cell proliferation and differentiation.|PTM:Constitutively sumoylated by SUMO1| SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is| itself| inhibited by Ras-activated phosphorylation on Thr-232.|PTM:Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated| in vitro| by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232| induced by HA-RAS| activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.|Belongs to the bZIP family.|Belongs to the bZIP family. Fos subfamily.|Contains 1 bZIP domain.|subunit:Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB.|
- Regulärer Preis
- €97,20 EUR
- Verkaufspreis
- €97,20 EUR
- Regulärer Preis
-
ADD TO CART
Product Specification
Basic Information
Brands:BT LAB
Model Number:
Place of Origin:China
Warranty:
Safety Performance:
Protection Class:
Sterile Status:
Reconstitution:
Shipping:
Battery:
Battery Service Life:
Component:
Technical Specifications
Capacity:
Concentration:1 mg/ml
Dimension [D×W×H]:
Diameter:
Length:
Width:
High:
Volume:
Volume Range:
Speed:
Speed Range:
Max.Speed:
Max. RCF:
Temperature Range:
Operating Temperature Range:
Permissible Ambient Temperature :
Permissible Relative Humidity:
Input voltage:
Power Requirements:
Voltage/Frequency:
Sensitivity:
Specificity:
Precision:
Speed Accuracy:
Volume Accuracy:
Particle Size:
Pore Size:
Binding Capacity:
Calculated Molecular Weight:
Observed Molecular Weight:
Purity:
Shelf Life:
Storage:-20°C for 1 year
Random Error:
Acceleration/Braking time:
Aspiration Speed:
Calculated Molecular Weight:
Dilution:
Driving Motor DC motor:
Em:
Ex:
Endotoxin:
Flow rate [liquid]:
Features and Capabilities
Application:WB, ELISA
Detection Target:FOS
Detection Type:
Detection Range:
Research Areas:Cancer; Epigenetics and nuclear signaling; Neuroscience
Species Reactivity:
Reactivity:Human, Mouse, Rat
Target Synonym:
Test Principle:
Quantitative/Qualitative :
Result Type:
Materials :
Assay Time:
Autoclave component:
Available Rotor Adapters:
Binding Capacity:
Bio-activity:
Bottom Shape:
Bottom Type:
Buffer:
Cap Color:
Clonality:Polyclonal
Conjugation:
Coupled Ligand:
Cover Type:
Detection Instrument :
Dispensing Speed:
Display:
Form:
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Graduation:
Growth Area: