BT LAB

Artikelnummer: BT-E1313Hu-96T

Human Alpha-Synuclein, SNCA ELISA Kit , 96T

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed: 28288128, PubMed: 30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed: 30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed: 20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed: 20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed: 26442590).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.15pg/ml

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Application:ELISA

Detection Target:SNCA

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Detection Range: 10-1000pg/ml

Research Areas:Neuroscience

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Test Principle:Sandwich

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Assay Time:1h 30m

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