{"product_id":"human-caspase-14-casp14-elisa-kit-96t","title":"Human Caspase 14, CASP14 ELISA Kit, 96T","description":"\u003cp\u003eNon-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed: 15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed: 16854378, PubMed: 19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed: 25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA\/ICAD leading to liberation of DFFB\/CAD (PubMed: 24743736).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592496984437,"sku":"BT-E2252Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-caspase-14-casp14-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}