BT LAB

Artikelnummer: BT-E4993Hu-96T

Human Caspase-6, CASP6 ELISA Kit , 96T

Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed: 8663580, PubMed: 32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed: 17401638, PubMed: 8663580, PubMed: 9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed: 10559921, PubMed: 14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed: 32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed: 32298652).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:7.79ng/L

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Application:ELISA

Detection Target:CASP6

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Detection Range: 15-3000ng/L

Research Areas:Neuroscience; Cell Biology; Cancer; Metabolism

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Test Principle:Sandwich

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Assay Time:1h 30m

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