{"product_id":"human-class-e-basic-helix-loop-helix-protein-41-bhlhe41-elisa-kit-96t","title":"Human Class E Basic Helix-Loop-Helix Protein 41, BHLHE41 ELISA Kit, 96T","description":"\u003cp\u003eTranscriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed: 11278948, PubMed: 14672706, PubMed: 15193144, PubMed: 15560782, PubMed: 18411297, PubMed: 19786558, PubMed: 25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER\/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1\/2 and CRY1\/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL\/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed: 25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41\/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA\/B\/G, NR1H3\/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592535617909,"sku":"BT-E3569Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-class-e-basic-helix-loop-helix-protein-41-bhlhe41-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}