BT LAB

Artikelnummer: BT-E0324Hu-96T

Human Complement Factor H, CFH ELISA Kit , 96T

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed: 21285368, PubMed: 25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed: 19503104). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed: 18252712, PubMed: 28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed: 9558116, PubMed: 20008295).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:4.88ng/ml

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Application:ELISA

Detection Target:CFH

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Detection Range: 10-3000ng/ml

Research Areas:Immunology

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Reactivity:Human

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Assay Time:1h 30m

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