BT LAB

Artikelnummer: BT-E3570Hu-96T

Human Cytochrome P450 3A5, CYP3A5 ELISA Kit, 96T

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed: 2732228, PubMed: 10681376, PubMed: 11093772, PubMed: 12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed: 12865317, PubMed: 2732228, PubMed: 10681376, PubMed: 11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed: 12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed: 2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed: 10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed: 11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium Channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed: 2732228).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.14ng/L

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Application:ELISA

Detection Target:CYP3A5

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Detection Range: 10-2000ng/L

Research Areas:Cardiovascular

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Test Principle:Sandwich

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Assay Time:1h 30m

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