{"product_id":"human-cytochrome-p450-3a5-cyp3a5-elisa-kit-96t","title":"Human Cytochrome P450 3A5, CYP3A5 ELISA Kit, 96T","description":"\u003cp\u003eA cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed: 2732228, PubMed: 10681376, PubMed: 11093772, PubMed: 12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed: 12865317, PubMed: 2732228, PubMed: 10681376, PubMed: 11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed: 12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed: 2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed: 10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed: 11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium Channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed: 2732228).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592535650677,"sku":"BT-E3570Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-cytochrome-p450-3a5-cyp3a5-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}