{"product_id":"human-dna-damage-binding-protein-2-ddb2-elisa-kit-96t","title":"Human DNA Damage-binding Protein 2, DDB2 ELISA Kit, 96T","description":"\u003cp\u003eProtein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed: 10882109, PubMed: 11278856, PubMed: 11705987, PubMed: 9892649, PubMed: 12732143, PubMed: 15882621, PubMed: 16473935, PubMed: 18593899). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed: 10882109, PubMed: 11278856, PubMed: 11705987, PubMed: 16260596, PubMed: 12944386, PubMed: 1$475.00|$350.001237). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed: 10882109, PubMed: 11278856, PubMed: 11705987, PubMed: 16260596, PubMed: 12944386). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed: 12732143, PubMed: 15882621, PubMed: 16473935, PubMed: 18593899, PubMed: 26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed: 16678110, PubMed: 16473935). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed: 16678110, PubMed: 16473935). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed: 15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7\/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7\/HBO1 following phosphorylation by ATR (PubMed: 26572825). [Isoform D1]: Inhibits UV-damaged DNA repair. [Isoform D2]: Inhibits UV-damaged DNA repair.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592655942005,"sku":"BT-E5189Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-dna-damage-binding-protein-2-ddb2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}