BT LAB

Artikelnummer: BT-E5272Hu-96T

Human Eyes Absent Homolog 2, EYA2 ELISA Kit, 96T

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed: 12500905, PubMed: 23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed: 19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed: 12500905).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:2.25ng/L

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Application:ELISA

Detection Target:EYA2

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Detection Range: 5-1000ng/L

Research Areas:Signal Transduction

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Test Principle:Sandwich

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Assay Time:1h 30m

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