{"product_id":"human-g-protein-coupled-receptor-kinase-5-grk5-elisa-kit-96t","title":"Human G-protein Coupled Receptor Kinase 5, GRK5 ELISA Kit, 96T","description":"\u003cp\u003eSerine\/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2\/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein\/ST13, TP53\/p53, HDAC5, and arrestin-1\/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1\/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53\/p53, a crucial tumor suppressor, inhibits TP53\/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592635429237,"sku":"BT-E4833Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-g-protein-coupled-receptor-kinase-5-grk5-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}