{"product_id":"human-glycogen-synthase-kinase-3-alpha-gsk3a-elisa-kit-96t","title":"Human Glycogen Synthase Kinase-3 Alpha, GSK3A ELISA Kit, 96T","description":"\u003cp\u003eConstitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen Synthase (GYS1 or GYS2), CTNNB1\/beta-catenin, APC and AXIN1 (PubMed: 11749387, PubMed: 17478001, PubMed: 19366350). Requires primed phosphorylation of the majority of its substrates (PubMed: 11749387, PubMed: 17478001, PubMed: 19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed: 11749387, PubMed: 17478001, PubMed: 19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed: 10868943, PubMed: 17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1\/beta-catenin (PubMed: 17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed: 12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5\/TIP60 under starvation conditions, leading to activate KAT5\/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL\/Pacer (PubMed: 30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592523493749,"sku":"BT-E3195Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-glycogen-synthase-kinase-3-alpha-gsk3a-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}