{"product_id":"human-homeobox-protein-nanog-nanog-elisa-kit-96t","title":"Human Homeobox Protein Nanog, NANOG ELISA Kit, 96T","description":"\u003cp\u003eTranscription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1\/OCT4 promoter (PubMed: 25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281\/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592664265077,"sku":"BT-E5432Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-homeobox-protein-nanog-nanog-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}