BT LAB

Artikelnummer: BT-E3080Hu-96T

Human Hypoxia-inducible Factor 1-alpha Inhibitor, HIF1AN ELISA Kit, 96T

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.09ng/L

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Application:ELISA

Detection Target:HIF1AN

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Detection Range: 10-2000ng/L

Research Areas:Others

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Assay Time:1h 30m

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