{"product_id":"human-inhibitor-of-growth-protein-4-ing4-elisa-kit-96t","title":"Human Inhibitor of Growth Protein 4, ING4 ELISA Kit, 96T","description":"\u003cp\u003eComponent of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed: 16387653). Through chromatin acetylation it may function in DNA replication (PubMed: 16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed: 15251430, PubMed: 15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA\/NFKB3 target genes when complexed with RELA (PubMed: 15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed: 15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed: 15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592664854901,"sku":"BT-E5465Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-inhibitor-of-growth-protein-4-ing4-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}