{"product_id":"human-interferon-induced-35-kda-protein-ifi35-elisa-kit-96t","title":"Human Interferon-induced 35 kDa Protein, IFI35 ELISA Kit, 96T","description":"\u003cp\u003eActs as a signaling pathway regulator involved in innate immune system response (PubMed: 26342464, PubMed: 29038465, PubMed: 29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed: 10779520, PubMed: 10950963). In complex with NMI, inhibits virus-triggered type I interferon\/IFN-beta production (PubMed: 26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65\/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed: 29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed: 29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4\/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (PubMed: 29038465).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592666427765,"sku":"BT-E5498Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-interferon-induced-35-kda-protein-ifi35-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}