{"product_id":"human-interleukin-enhancer-binding-factor-3-ilf3-elisa-kit-96t","title":"Human Interleukin Enhancer-binding Factor 3, ILF3 ELISA Kit, 96T","description":"\u003cp\u003eRNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed: 28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed: 14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed: 21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase\/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed: 21123651, PubMed: 28625552).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592666526069,"sku":"BT-E5503Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-interleukin-enhancer-binding-factor-3-ilf3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}