{"product_id":"human-kelch-like-ech-associated-protein-1-keap1-elisa-kit-96t","title":"Human Kelch-like Ech-associated Protein 1, KEAP1 ELISA Kit, 96T","description":"\u003cp\u003eSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2\/NRF2 for ubiquitination (PubMed: 1$458.00|$300.005973, PubMed: 15379550, PubMed: 15572695, PubMed: 15983046, PubMed: 15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2\/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed: 15601839, PubMed: 16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2\/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed: 19489739, PubMed: 16006525, PubMed: 17127771, PubMed: 18251510, PubMed: 29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1\/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2\/NRF2 (PubMed: 20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1\/p62, increasing SQSTM1\/p62 sequestering activity and degradation (PubMed: 28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed: 15379550, PubMed: 17046835).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592667443573,"sku":"BT-E5534Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-kelch-like-ech-associated-protein-1-keap1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}