{"product_id":"human-la-related-protein-1-larp1-elisa-kit-96t","title":"Human La-related Protein 1, LARP1 ELISA Kit, 96T","description":"\u003cp\u003eRNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed: 20430826, PubMed: 23711370, PubMed: 24532714, PubMed: 25940091, PubMed: 28650797, PubMed: 28673543, PubMed: 29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed: 23711370, PubMed: 25940091, PubMed: 28650797, PubMed: 29244122, PubMed: 26206669, PubMed: 28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed: 25940091, PubMed: 28650797, PubMed: 29244122, PubMed: 28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed: 25940091, PubMed: 28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed: 28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed: 20430826, PubMed: 24532714, PubMed: 25940091, PubMed: 28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed: 23711370, PubMed: 28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed: 20430826, PubMed: 24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed: 20430826, PubMed: 23711370, PubMed: 25940091, PubMed: 28673543). (Microbial infection) Positively regulates the replication of dengue virus (DENV).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592668033397,"sku":"BT-E5556Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-la-related-protein-1-larp1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}