{"product_id":"human-myeloid-cell-surface-antigen-cd33-cd33-elisa-kit-96t","title":"Human Myeloid Cell Surface Antigen Cd33, CD33 ELISA Kit , 96T","description":"\u003cp\u003eSialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 15597323, PubMed: 11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 28325905, PubMed: 10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6\/SHP-1 and PTPN11\/SHP-2 (PubMed: 10556798, PubMed: 10206955, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase\/PI3K (PubMed: 15597323).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592671048053,"sku":"BT-E5714Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-myeloid-cell-surface-antigen-cd33-cd33-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}