BT LAB

Artikelnummer: BT-E4156hu-96T

Human Nadphoxidase 4, NOX4 ELISA Kit, 96T

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium Channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [Isoform 4]: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:2.36ng/L

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Application:ELISA

Detection Target:NOX4

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Detection Range: 5-1500ng/L

Research Areas:Cardiovascular

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Reactivity:Human

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Test Principle:Sandwich

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Assay Time:1h 30m

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