{"product_id":"human-nadphoxidase-4-nox4-elisa-kit-96t","title":"Human Nadphoxidase 4, NOX4 ELISA Kit, 96T","description":"\u003cp\u003eConstitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA\/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3\/TASK-1 potassium Channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [Isoform 4]: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1\/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592558948725,"sku":"BT-E4156hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-nadphoxidase-4-nox4-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}