{"product_id":"human-nuclear-mitotic-apparatus-protein-1-numa1-elisa-kit-96t","title":"Human Nuclear Mitotic Apparatus Protein 1, NUMA1 ELISA Kit, 96T","description":"\u003cp\u003eMicrotubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed: 7769006, PubMed: 17172455, PubMed: 19255246, PubMed: 24996901, PubMed: 26195665, PubMed: 27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed: 12445386, PubMed: 11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed: 23870127, PubMed: 24109598, PubMed: 24996901, PubMed: 26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed: 23027904, PubMed: 22327364, PubMed: 23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed: 22327364, PubMed: 23921553, PubMed: 24996901, PubMed: 24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed: 24996901, PubMed: 24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed: 21816348). Plays a role in mitotic MT aster assembly (PubMed: 11163243, PubMed: 11229403, PubMed: 12445386). Involved in anastral spindle assembly (PubMed: 25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed: 16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed: 10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592516710773,"sku":"BT-E2971Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-nuclear-mitotic-apparatus-protein-1-numa1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}