BT LAB

Artikelnummer: BT-E5802Hu-96T

Human Nucleophosmin, NPM1 ELISA Kit , 96T

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed: 22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed: 25956029).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:7.28ng/L

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Application:ELISA

Detection Target:NPM1

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Detection Range: 15-3000ng/L

Research Areas:Epigenetics and Nuclear Signaling

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Test Principle:Sandwich

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Assay Time:1h 30m

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