{"product_id":"human-nucleophosmin-npm1-elisa-kit-96t","title":"Human Nucleophosmin, NPM1 ELISA Kit , 96T","description":"\u003cp\u003eInvolved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53\/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic\/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2\/PKR and suppresses apoptosis through inhibition of EIF2AK2\/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2\/M blockade (PubMed: 22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed: 25956029).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592675275125,"sku":"BT-E5802Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-nucleophosmin-npm1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}