BT LAB

Artikelnummer: BT-E2414Hu-96T

Human Opsin 5, OPN5 ELISA Kit, 96T

G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed: 22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:0.07ng/ml

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Application:ELISA

Detection Target:OPN5

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Detection Range: 0.2-60ng/ml

Research Areas:Neuroscience; Cardiovascular

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Test Principle:Sandwich

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Assay Time:1h 30m

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