BT LAB

Artikelnummer: BT-E5936Hu-96T

Human Pro-nerve Growth Factor, PRONGF ELISA Kit , 96T

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed: 14976160, PubMed: 20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed: 20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed: 20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:0.019ng/mL

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Application:ELISA

Detection Target:NGF

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Detection Range: 0.05-20ng/mL

Research Areas:Neuroscience

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Test Principle:Sandwich

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Assay Time:1h 30m

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