{"product_id":"human-protein-arginine-deiminase-type-4-padi4-elisa-kit-96t","title":"Human Protein-arginine Deiminase Type-4, PADI4 ELISA Kit, 96T","description":"\u003cp\u003eCatalyzes the citrullination\/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed: 15339660, PubMed: 15345777, PubMed: 16567635, PubMed: 21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and\/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed: 15339660, PubMed: 15345777, PubMed: 16567635, PubMed: 21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed: 15339660, PubMed: 15345777, PubMed: 16567635, PubMed: 21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed: 18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2\/PRMT1 and represses transcription (PubMed: 15345777). Citrullinates EP300\/P300 at 'Arg-2142', which favors its interaction with NCOA2\/GRIP1 (PubMed: 15731352).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592550003061,"sku":"BT-E4079hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-protein-arginine-deiminase-type-4-padi4-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}