{"product_id":"human-selenoprotein-n-seln-elisa-kit-96t","title":"Human Selenoprotein N, SELN ELISA Kit, 96T","description":"\u003cp\u003e[Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed: 25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed: 19557870, PubMed: 18713863). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed: 21131290).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592570417525,"sku":"BT-E4240hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-selenoprotein-n-seln-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}