BT LAB

Artikelnummer: BT-E3141Hu-96T

Human Sialidase-4, NEU4 ELISA Kit, 96T

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed: 15847605, PubMed: 21521691, PubMed: 15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed: 21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed: 15847605).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:10.17ng/L

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Application:ELISA

Detection Target:NEU4

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Detection Range: 20-6000ng/L

Research Areas:Neuroscience

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Test Principle:Sandwich

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Assay Time:1h 30m

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