{"product_id":"human-signal-transducer-and-activator-of-transcription-3-stat3-elisa-kit-96t","title":"Human Signal Transducer and Activator of Transcription 3, STAT3 ELISA Kit , 96T","description":"\u003cp\u003eSignal transducer and transcription activator that mediates cellular responses to interleukins, KITLG\/SCF, LEP and other growth factors (PubMed: 10688651, PubMed: 12359225, PubMed: 12873986, PubMed: 15194700, PubMed: 17344214, PubMed: 18242580, PubMed: 23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed: 17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed: 12873986). Upon activation of IL6ST\/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed: 12359225). Activated by IL31 through IL31RA (PubMed: 15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed: 28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed: 17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed: 18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2\/PKR activity (PubMed: 23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592473293173,"sku":"BT-E0650Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-signal-transducer-and-activator-of-transcription-3-stat3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}