BT LAB

Artikelnummer: BT-E6179Hu-96T

Human Slam Family Member 7, SLAMF7 ELISA Kit , 96T

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed: 11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed: 16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed: 11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed: 23695528). Isoform 3 does not mediate any NK cell activation.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:14.56ng/L

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Application:ELISA

Detection Target:SLAMF7

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Detection Range: 30-9000ng/L

Research Areas:Immunology

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Test Principle:Sandwich

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Assay Time:1h 30m

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