{"product_id":"human-sorting-nexin-2-snx2-elisa-kit-96t","title":"Human Sorting Nexin 2, SNX2 ELISA Kit, 96T","description":"\u003cp\u003eInvolved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed: 16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed: 17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed: 23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed: 20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed: 20604901).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592505405813,"sku":"BT-E2548Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-sorting-nexin-2-snx2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}