BT LAB

Artikelnummer: BT-E2607Hu-96T

Human Tnf Receptor Associated Factor 6, TRAF6 ELISA Kit, 96T

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:9.57ng/L

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Application:ELISA

Detection Target:TRAF6

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Detection Range: 20-3500ng/L

Research Areas:Signal Transduction

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Test Principle:Sandwich

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Assay Time:1h 30m

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