BT LAB

Artikelnummer: BT-E0334Hu-96T

Human Toll-like Receptor 7, TLR7 ELISA Kit , 96T

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed: 14976261, PubMed: 32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed: 31608988, PubMed: 27742543, PubMed: 12738885). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed: 27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed: 27742543).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.32ng/L

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Application:ELISA

Detection Target:TLR7

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Detection Range: 10-3500ng/L

Research Areas:Immunology; Signal Transduction; Epigenetics and Nuclear Signaling

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Reactivity:Human

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Test Principle:Sandwich

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Assay Time:1h 30m

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