{"product_id":"human-toll-like-receptor-8-tlr8-elisa-kit-96t","title":"Human Toll-like Receptor 8, TLR8 ELISA Kit , 96T","description":"\u003cp\u003eEndosomal receptor that plays a key role in innate and adaptive immunity (PubMed: 25297876, PubMed: 32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed: 31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed: 23520111, PubMed: 25599397, PubMed: 26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed: 16737960, PubMed: 17932028, PubMed: 29155428).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592472113525,"sku":"BT-E0375Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-toll-like-receptor-8-tlr8-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}