{"product_id":"human-triggering-receptor-expresses-on-myeloid-cells-1-trem-1-elisa-kit-96t","title":"Human Triggering Receptor Expresses On Myeloid Cells-1, TREM-1 ELISA Kit , 96T","description":"\u003cp\u003e[Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed: 10799849, PubMed: 21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP\/DAP12 (PubMed: 25595774, PubMed: 17568691, PubMed: 29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed: 21659545, PubMed: 14656437). This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and\/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed: 17568691, PubMed: 17098818). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed: 21393102, PubMed: 11323674). [Isoform 2]: Acts as a decoy receptor, counterbalancing TREM1 proinflammatory activity through the neutralization of its lignad.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592471064949,"sku":"BT-E0269Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-triggering-receptor-expresses-on-myeloid-cells-1-trem-1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}